Hexokinase Isozyme in Human Liver: Altered Isozyme Distribution among Liver Diseases
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چکیده
منابع مشابه
Hexokinase isozyme distribution in human skeletal muscle.
Two isoforms of hexokinase (type I and type II) are expressed in skeletal muscle; however, the intracellular distribution of these hexokinase isoforms in human skeletal muscle is unclear. The current study was undertaken to assess this issue because binding of hexokinase to subcellular structures is considered to be an important mechanism in the regulation of glucose phosphorylation. Vastus lat...
متن کاملIdentification of the UDP-glucuronosyltransferase isozyme involved in senecionine glucuronidation in human liver microsomes.
Senecionine (SEN) is a representative of the hepatotoxic pyrrolizidine alkaloids. Although phase I metabolism for cytochrome P450-mediated metabolic activation of SEN was investigated extensively, phase II metabolism for glucuronidation of this compound has not been investigated until now. In our present study, one unique glucuronidation product of SEN in human liver microsomes (HLMs) was ident...
متن کاملIdentification of the UGT isozyme involved in senecionine glucuronidation in human liver microsomes
The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201210, China (Y.-Q. H, B.-F. Z, Li Y., A.-Z. X, L.-L. X., C.-H. W., Z.-T. W.); Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Dalian, 116023, China (Y. L., Ling Y. H.-X. L.); Affilated Longhua Hospital of Shangh...
متن کاملInteraction of Mg2+ with human liver aldehyde dehydrogenase. I. Species difference in the mitochondrial isozyme.
The dehydrogenase activity of the mitochondrial isozyme (E2) of human liver aldehyde dehydrogenase was stimulated about 2-fold by the presence of low concentrations (about 120-140 microM) of Mg2+ in the assay at pH 7.0 using propionaldehyde as substrate. The stimulation was totally reversible by treatment with EDTA. Maximum stimulation was dependent on the concentration of NAD+ used in the assa...
متن کاملUDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes.
Glucuronidation is an important pathway in the metabolism of protocatechuic aldehyde (3,4-dihydroxybenzaldehyde, PAL). However, the metabolites and primary UDP-glucuronosyltransferase (UGT) isozymes responsible for PAL glucuronidation remain to be determined in human. Here, we characterized PAL glucuronidation by human liver microsomes (HLMs), human intestine microsomes (HIMs), and 12 recombina...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1975
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.16.503